| VLA | Very Large Array Radio Telescope in Arizona or New Mexico |
| XXXL | Extremely Extra Extra Large |
| ELF | Extremely Low Frequency |
| EHF | Extremely High Frequency [30-300GHz] |
| NTT | New Technology Telescope |
| MMT | Multiple Mirror Telescope |
| SAT | Synthetic Aperture Telescope |
| SCT | Schmidt-Cassegrain Telescope |
| Hst | Hubble Space Telescope |
| OTA | Optical Telescope Assembly |
| GBT | Green Bank Telescope |
| CFHT | Canada-France-Hawaii Telescope NGO-Teleskop Betreiber, http://www.cfht.hawaii.edu |
| CIT | Circumstellar Imaging Telescope [Weltraum] |
| iota | Infrared-Optical Telescope Array |
| LHST | Live from the Hubble Space Telescope |
| UKST | United Kingdom Schmidt Telescope |
| ATM | Amateur Telescope Maker [engl.] |
| HUT | Hopkins Ultraviolet Telescope [ASTRO Packet] |
| UIT | Ultraviolet Imaging Telescope [Astro package] |
| GMRT | Giant Meter-wave Radio Telescope |
| WIYN | Wisconsin / Indiana / Yale / NOAO telescope |
| COSAC | Conference of Community and European Affairs Committees of Parliaments of the European Union Konferenz der Europaausschüsse der nationalen Parlamente |
| XL | Extra Large |
| LOB | Large Object |
| VLM | Very Large Memory |
| L | Large [size] |
| LPS | Large Poincare System |
| LFP | Large Format Printing |
| LHC | Large Hadron Collider |
| LSI | Large Scale Integration |
| VLSI | Very Large Scale Integration |
| VLCC | Very Large Crude Carrier |
| LMC | Large Magellanic Cloud [see SMC] |
| VLDB | Very Large Data Base |
| LFF | Large Form Factor |
| CLOB | Character Large OBject |
| LEAF | Large Effective Area Fiber |
| PLSI | Programmable Large Scale Integration |
| LIPX | Large Internet Packet Exchange |
| LISA | Large Installation System Administration |
| LDF | Large Deployable Reflector [Weltraum] |
| SLED | Single Large Expensive Disk |
| SLSI | Super Large Scale Integration |
| BLOB | Binary Large Object [engl.] Grosse zusammenhängende Datenmengen |
| ULSI | Ultra Large Scale Integration |
| VLSIC | Very Large Scale Integration Circuit |
| LCG | Large Hadron Collider Computing GRID Genf, lcg.web.cern.ch/LCG |
| LCG | Large-Curvature Ground state approximation |
| LIEP | Large Internet Exchange Packet [Novell] |
| NRLH | Nonrigid Rotation Large-amplitude Hamiltonian |