| USB | Universal Serial Bus |
| WUSB | Wireless Universal Serial Bus |
| SIPO | Serial In/ Serial Out |
| SISO | Serial In, Serial Out |
| SATA | Serial AT Bus Attachment |
| SBP | Serial Bus Protocol |
| SSA | Serial Storage Architecture [IBM] |
| SAS | Serial Attached SCSI |
| SCC | Serial Controller Chip |
| SIA | Serial Interface Adapter |
| SIE | Serial Interface Engine |
| SIO | Serial Input Output |
| SSP | Serial Storage Protocol |
| SSI | SCSI Serial Interface |
| SPD | Serial Presence Detect |
| SPI | Serial Peripheral Interface |
| SPP | Serial Port Profile |
| SAM | Serial Access Memory |
| ESN | Electronic Serial Number |
| ESP | Enhanced Serial Port |
| ESI | Enhanced Serial Interface |
| ESI | Enhanced Serial Interface |
| PSN | Processor Serial Number |
| SCC | Serial Communication Controller |
| SSCC | Serial Shipping Container Code |
| SSDA | Synchronous Serial Data Adapter |
| ASN | Army Serial Number [engl.] |
| SCMS | Serial Copy Management System |
| HPSB | High Performance Serial Bus [FireWire] |
| SDI | Serial Device / Digital Interface |
| SDDI | Serial Digital Data Interface |
| SAGE | Serial Analysis of Gene Expression |
| CSN | Card Serial Number [engl.] |
| ISSN | International Standard Serial Number Internationale Standardnummer für fortlaufende Sammelwerke |
| HSSO | High Speed Serial Output [engl.] Schnittstelle bei DAB-Geräten |
| CSLIP | Compressed Serial Line Internet Protocol. |
| HSSI | High Speed Serial Interface [engl.] |
| MCBSP | Multi Channel Buffered Serial Port |
| SLIP | Serial Line Interface Protocol [Internet] |
| SIR | Serial Infrared Communication [Hewlett-Packard] |
| HSSDC | High Speed Serial Data Connection [engl.] Steckverbinder |
| UDB | Universal Database |
| UC | Universal Code |
| UT | Universal Time |
| UPC | Universal Product Code |
| UNO | Universal Network Objects |
| UPC | Universal Printer Controller |
| ULN | Universal Link Negotiation |
| UNL | Universal Networking Language |
| UNIVAC | Universal Automatic Computer |